Oral progesterone for the prevention of recurrent preterm birth: systematic review and metaanalysis

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Progesterone for the prevention of preterm birth: a systematic review.

OBJECTIVE We performed a systematic review to assess the benefits and harms of progesterone administration for the prevention of preterm birth in women and their infants. DATA SOURCES The Cochrane Controlled Trials Register was searched, and reference lists of retrieved studies were searched by hand. No date or language restrictions were placed. METHODS OF STUDY SELECTION Randomized trials ...

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The use of progesterone for prevention of preterm birth.

OBJECTIVE To introduce new information on the use of progesterone to prevent premature labour and to provide guidance to obstetrical caregivers who counsel women on the merits of this choice OPTIONS This discussion is limited to progesterone therapy for prevention of preterm labour (PTL) in women at increased risk of PTL. EVIDENCE A search of both Medline and the Cochrane Library identified...

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The short-term prediction of preterm birth: a systematic review and diagnostic metaanalysis.

OBJECTIVE To assess the diagnostic accuracy of fetal fibronectin (fFN), fetal breathing movements (FBM), and cervical length (CL) for the short-term prediction of preterm birth in symptomatic patients. STUDY DESIGN Diagnostic metaanalysis using bivariate methods. RESULTS Pooled sensitivities for fFN, FBM, and CL for delivery within 48 hours of testing were 0.62 (95% confidence interval [CI]...

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The role of progesterone in prevention of preterm birth

Preterm birth continues to provide an enormous challenge in the delivery of perinatal health care, and is associated with considerable short and long-term health consequences for surviving infants. Progesterone has a role in maintaining pregnancy, by suppression of the calcium-calmodulin-myosin light chain kinase system. Additionally, progesterone has recognized anti-inflammatory properties, ra...

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Progesterone for preterm birth prevention: an evolving intervention.

We sought to review emerging data on the use of progesterone to prevent preterm birth (PTB). Using the terms "preterm or premature" and "progesterone" we queried the PubMed database, restricting our search to January 1, 2000, forward and selected randomized clinical trials (RCTs) and metaanalyses of RCTs that evaluated the use of progesterone for the prevention of PTB. We reviewed 238 abstracts...

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ژورنال

عنوان ژورنال: American Journal of Obstetrics & Gynecology MFM

سال: 2019

ISSN: 2589-9333

DOI: 10.1016/j.ajogmf.2019.03.001